Quinone mediated electron transport system in the filarial parasite Setaria digitata
Biochemical and Biophysical Research Communications, ISSN: 0006-291X, Vol: 174, Issue: 1, Page: 386-392
1991
- 10Citations
- 4Captures
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Article Description
Setaria digitata, a cattle filarial parasite, is known to have peculiarities such as hydrogen peroxide (H 2 O 2 ) production, cyanide insensitivity, absence of cytochromes and presence of quinones. Estimation of mitochondrial H 2 O 2 with different substrates and inhibitors showed that salicylhydroxamic acid (SHAM), the alternative oxidase inhibitor, inhibited the H 2 O 2 production maximally. Based on the inhibitory studies with rotenone, antimycin A, o-hydroxydiphenyl, SHAM and 2 thenoyltrifluoroacetone, a mechanism for the electron transport is proposed. Quinone Q 8 seems to have a central role, hence inhibitors at the level of quinones might prove to be effective in designing drugs for filariasis.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/0006291X9190532C; http://dx.doi.org/10.1016/0006-291x(91)90532-c; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0026027554&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/1989617; https://linkinghub.elsevier.com/retrieve/pii/0006291X9190532C; http://linkinghub.elsevier.com/retrieve/pii/0006291X9190532C; http://api.elsevier.com/content/article/PII:0006291X9190532C?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:0006291X9190532C?httpAccept=text/plain; http://dx.doi.org/10.1016/0006-291x%2891%2990532-c; https://dx.doi.org/10.1016/0006-291x%2891%2990532-c
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