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The existence of unique B structures in polynucleotides with alternating purine-pyrimidine sequences

Biochemical and Biophysical Research Communications, ISSN: 0006-291X, Vol: 174, Issue: 3, Page: 1313-1317
1991
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The infrared spectra of the sodium salts of calf-thymus DNA, poly(dA-dC)·poly(dG-dT), poly(dA-dT) and poly(dG-dC) were measured for the samples as highly hydrated, nonoriented gels. The bands from the sugar-phosphate vibrational modes show that poly(dG-dC) assumes a B-family structure which is different from the B structures of the other samples. Poly(dG-dC) most likely assumes a wrinkled B structure. The other samples retain a smooth B structure. An alternating purine-pyrimidine sequence is not a sufficient condition for the formation of wrinkled B structure in a polynucleotide.

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