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Increases in cytochrome P-450 in cultured hepatocytes mediated by 3- and 4-carbon alcohols

Biochemical Pharmacology, ISSN: 0006-2952, Vol: 31, Issue: 17, Page: 2811-2815
1982
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Article Description

The amount of cytochrome P-450 was increased to different extents after treatment of cultured chick embryo hepatocytes with n -propanol, isopropanol, n -butanol, or isobutanol, These increases were associated with increases in benzphetamine demethylase activity, a cytochrome P-450-catalyzed oxidation, and glucuronidation of phenol red, catalyzed by UDP-glucuronyl transferase. The responses were similar to those obtained with ethanol or propylisopropylacetamide, which are phenobarbital-like inducers. Pretreatment of cells with cycloheximide prevented the increases in both cytochrome P-450 and glucuronidation of phenol red, indicating that protein synthesis was required for these responses.

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