Increases in cytochrome P-450 in cultured hepatocytes mediated by 3- and 4-carbon alcohols
Biochemical Pharmacology, ISSN: 0006-2952, Vol: 31, Issue: 17, Page: 2811-2815
1982
- 33Citations
- 3Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations33
- Citation Indexes31
- 31
- CrossRef23
- Policy Citations2
- Policy Citation2
- Captures3
- Readers3
Article Description
The amount of cytochrome P-450 was increased to different extents after treatment of cultured chick embryo hepatocytes with n -propanol, isopropanol, n -butanol, or isobutanol, These increases were associated with increases in benzphetamine demethylase activity, a cytochrome P-450-catalyzed oxidation, and glucuronidation of phenol red, catalyzed by UDP-glucuronyl transferase. The responses were similar to those obtained with ethanol or propylisopropylacetamide, which are phenobarbital-like inducers. Pretreatment of cells with cycloheximide prevented the increases in both cytochrome P-450 and glucuronidation of phenol red, indicating that protein synthesis was required for these responses.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/0006295282901381; http://dx.doi.org/10.1016/0006-2952(82)90138-1; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0019941233&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/7138576; https://linkinghub.elsevier.com/retrieve/pii/0006295282901381; http://dx.doi.org/10.1016/0006-2952%2882%2990138-1; https://dx.doi.org/10.1016/0006-2952%2882%2990138-1
Elsevier BV
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