Studies on the cyanamide-ethanol interaction
Biochemical Pharmacology, ISSN: 0006-2952, Vol: 31, Issue: 11, Page: 1999-2004
1982
- 35Citations
- 2Captures
Metric Options: Counts1 Year3 YearSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Article Description
Administration of dimethylcyanamide (DMC) to rats caused a marked elevation in ethanol-derived blood acetaldehyde (AcH) and depressed the specific activity of the low K m mitochondrial aldehyde dehydrogenase (AlDH) by 90% at 12–24 hr, coincident with depletion of hepatic glutathione levels. Comparison of the relative efficacy of DMC and cyanamide in elevating blood AcH measured at 2hr and 1 hr post-drug treatment, respectively, indicated that DMC was at least one-fifth as active as cyanamide. However, since the comparison was not made at optimal times for DMC (12–24 hr), it is likely that its activity in vivo approaches that of cyanamide itself. DMC was essentially inactive in vitro as an inhibitor of the low K m AlDH isozyme in intact rat liver mitochondria. Although methylcyanamide, the product of N -demethylation of DMC, was too unstable to be prepared for this evaluation, the higher monoalkyl cyanamide, n -propylcyanamide, was synthesized chemically and was shown to be a good inhibitor of the mitochondrial enzyme in vitro. These results suggest that DMC must be N -demethylated before being converted to a reactive species that inhibits AlDH activity.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/0006295282904129; http://dx.doi.org/10.1016/0006-2952(82)90412-9; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0019981217&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/7115421; https://linkinghub.elsevier.com/retrieve/pii/0006295282904129; http://dx.doi.org/10.1016/0006-2952%2882%2990412-9; https://dx.doi.org/10.1016/0006-2952%2882%2990412-9
Elsevier BV
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