Induction of cytochrome P-450 and related drug-metabolizing activities in the livers of different rodent species by 2-acetylaminofluorene or by 3-methylcholanthrene
Biochemical Pharmacology, ISSN: 0006-2952, Vol: 35, Issue: 16, Page: 2703-2713
1986
- 23Citations
- 1Captures
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Metrics Details
- Citations23
- Citation Indexes22
- 22
- CrossRef16
- Policy Citations1
- 1
- Captures1
- Readers1
Article Description
In general, large differences in the control levels of different cytochrome P-450-catalyzed activities (aminopyrine N -demethylase, benzo( a )pyrene monooxygenase, ethoxyresorufin O -deethylase, ethoxycoumarin O -deethylase and total 2-acetylaminofluorene metabolism and metabolite pattern) and in the inducibility of these activities in different rodent species (rat, hamster, guinea pig and mouse) and sexes were observed. (1) For all the activities measured the lowest levels were observed in untreated rats. (2) With a few minor exceptions, the only species tested in which cytochrome P-450-catalyzed activities were induced by treatment with 2-acetylaminofluorene was the rat. (3) A larger number of the species tested were susceptible to induction by 3-methylcholanthrene. However, this xenobiotic proved also to induce most potently in the rat. (4) There are relatively large differences between the male and female rat both in terms of control cytochrome P-450-catalyzed activities and in the inducibility of these activities by 2-acetylaminofluorene and 3-methylcholanthrene. In general, both of these xenobiotics proved to be more potent inducers in the female than in the male.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/0006295286901784; http://dx.doi.org/10.1016/0006-2952(86)90178-4; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0022484137&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/3488741; https://linkinghub.elsevier.com/retrieve/pii/0006295286901784; http://dx.doi.org/10.1016/0006-2952%2886%2990178-4; https://dx.doi.org/10.1016/0006-2952%2886%2990178-4
Elsevier BV
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