Gemfibrozil modifies acyl composition of liver microsomal phospholipids from guinea-pigs without promoting peroxisomal proliferation
Biochemical Pharmacology, ISSN: 0006-2952, Vol: 46, Issue: 8, Page: 1515-1518
1993
- 8Citations
- 8Captures
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Metrics Details
- Citations8
- Citation Indexes8
- CrossRef8
- Captures8
- Readers8
Article Description
Treatment with gemflbrozil modifies acyl composition of hepatic microsomal phosphatidylcholine and phosphatidylethanolamine in guinea-pigs. Palmitic (16:0) and palmitoleic (16:1) fatty acids are increased, and stearic (18:0) and oleic (18:1) are decreased; further, while linoleic acid [18:2 (n-6)] is increased by gemfibrozil treatment, the other constituents of the n-6 fatty acids family, including arachidonic acid [20:4 (n-6)], are decreased. As gemfibrozil is a potent inhibitor of fatty acid elongation in vitro (Sánchez et al., FEBS Lett 300 : 89–92, 1992), the inhibition of this enzyme system by gemfibrozil treatment could be responsible for the observed results in vivo. These changes in fatty acid composition are accompanied by a decrease in serum lipids and, more important, are independent of peroxisomal proliferation.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/000629529390121C; http://dx.doi.org/10.1016/0006-2952(93)90121-c; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0027432113&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/8240405; http://linkinghub.elsevier.com/retrieve/pii/000629529390121C; http://api.elsevier.com/content/article/PII:000629529390121C?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:000629529390121C?httpAccept=text/plain; https://linkinghub.elsevier.com/retrieve/pii/000629529390121C; http://dx.doi.org/10.1016/0006-2952%2893%2990121-c; https://dx.doi.org/10.1016/0006-2952%2893%2990121-c
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