Panaxynol, a polyacetylene compound isolated from oriental medicines, inhibits mammalian lipoxygenases
Biochemical Pharmacology, ISSN: 0006-2952, Vol: 48, Issue: 10, Page: 1979-1981
1994
- 78Citations
- 14Captures
Metric Options: Counts1 Year3 YearSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations78
- Citation Indexes78
- 78
- CrossRef63
- Captures14
- Readers14
- 14
Article Description
Panaxynol is a polyacetylene compound isolated from commonly used oriental medicines, and its effects on various cyclooxygenases and lipoxygenases were investigated. The compound had only a marginal effect on cyclooxygenase activities (IC 50 values ⪢ 100 μ M), but inhibited lipoxygenases: 5-lipoxygenase (IC 50, 2 μM), two isoforms of 12-lipoxygenase (leukocyte-type, 1 μM; platelet-type, 67 μM) and 15-lipoxygenase (4 μM). Thus, panaxynol inhibited leukocyte-type 12-lipoxygenase much more effectively than platelet-type 12-lipoxygenase. Falcarindiol, an analogue of panaxynol, inhibited these lipoxygenases with higher IC 50 values than panaxynol. These compounds could provide a clue to develop a selective inhibitor of one isoform of 12-lipoxygenase.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/0006295294905983; http://dx.doi.org/10.1016/0006-2952(94)90598-3; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0027985790&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/7986211; https://linkinghub.elsevier.com/retrieve/pii/0006295294905983; http://dx.doi.org/10.1016/0006-2952%2894%2990598-3; https://dx.doi.org/10.1016/0006-2952%2894%2990598-3
Elsevier BV
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know