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Panaxynol, a polyacetylene compound isolated from oriental medicines, inhibits mammalian lipoxygenases

Biochemical Pharmacology, ISSN: 0006-2952, Vol: 48, Issue: 10, Page: 1979-1981
1994
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Panaxynol is a polyacetylene compound isolated from commonly used oriental medicines, and its effects on various cyclooxygenases and lipoxygenases were investigated. The compound had only a marginal effect on cyclooxygenase activities (IC 50 values ⪢ 100 μ M), but inhibited lipoxygenases: 5-lipoxygenase (IC 50, 2 μM), two isoforms of 12-lipoxygenase (leukocyte-type, 1 μM; platelet-type, 67 μM) and 15-lipoxygenase (4 μM). Thus, panaxynol inhibited leukocyte-type 12-lipoxygenase much more effectively than platelet-type 12-lipoxygenase. Falcarindiol, an analogue of panaxynol, inhibited these lipoxygenases with higher IC 50 values than panaxynol. These compounds could provide a clue to develop a selective inhibitor of one isoform of 12-lipoxygenase.

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