Veratridine-induced release in vivo and in vitro of amino acids in the rabbit olfactory bulb
Brain Research, ISSN: 0006-8993, Vol: 299, Issue: 1, Page: 103-112
1984
- 57Citations
- 5Captures
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations57
- Citation Indexes57
- CrossRef57
- 54
- Captures5
- Readers5
Article Description
Free amino acids were studied in the olfactory bulb of the rabbit during basal conditions and veratridine-induced depolarization, in vitro with a tissue slice preparation and in vivo with a perfusion-dialysis technique. In vivo, basal extracellular concentrations of GABA, β-alanine and aspartate were low, while glutamine showed the highest level. The basal steady-state concentration ratio between the total tissue pool of free amino acids and the extracellular fluid was high for GABA, aspartate and glutamate, while low for glutamine and other ‘non-transmitter’ amino acids. Veratridine induced a marked TTX-sensitive release of GABA (40–50 times the control) both in vivo and in vitro. In vivo, the GABA release showed a peak during the first minutes of veratridine perfusion. The TTX-sensitive release of aspartate and glutamate, on the other hand, was approximately 5 times higher in vitro than in vivo. Furthermore, a prolonged response to veratridine was seen for glutamate and aspartate in vivo consisting of an early peak, followed by a sustained release. Taurine showed a time-delayed veratridine response, both in vivo and in vitro, whereas glutamine displayed a slow, TTX-sensitive decrease. No effect of veratridine was seen on β-alanine or carnosine-threonine levels.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/0006899384907923; http://dx.doi.org/10.1016/0006-8993(84)90792-3; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0021333015&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/6144366; https://linkinghub.elsevier.com/retrieve/pii/0006899384907923; http://dx.doi.org/10.1016/0006-8993%2884%2990792-3; https://dx.doi.org/10.1016/0006-8993%2884%2990792-3
Elsevier BV
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know