Hierarchy of cytotoxic T cell clones
Cellular Immunology, ISSN: 0008-8749, Vol: 122, Issue: 2, Page: 471-482
1989
- 2Citations
- 2Captures
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Article Description
Cells from clones of anti-hapten marine cytotoxic T lymphocytes (CTL) can act as both target and effector cells, but will not lyse members of the same clone. The effect of haptenation on the cytolytic activity of anti-fluorescein (FL) and anti-trinitrophenol (TNP) CTL clones was examined. Treatment of anti-FL clones with fluorescein isothiocyanate or anti-TNP clones with trinitrobenzene sulphonic acid induces these clones to kill in an antigen-independent fashion. Targets killed by the haptenated CTL included syngeneic and allogeneic B lymphocyte blast cells, P815, YAC-1 and in one case human GM 4072 tumor cells. The importance of CD8 and T cell receptor (TCR) occupancy is demonstrated by the ability to block autotriggering by antibody directed against Ly 2 and the TCR. The results demonstrate that effects other than antigen recognition of the target play a role in the final outcome of effector-target cell interactions and provide a mechanism which could lead to autodestruction and immunosuppression particularly in some types of viral infection.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/0008874989900932; http://dx.doi.org/10.1016/0008-8749(89)90093-2; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0024423783&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/2504498; https://linkinghub.elsevier.com/retrieve/pii/0008874989900932; http://dx.doi.org/10.1016/0008-8749%2889%2990093-2; https://dx.doi.org/10.1016/0008-8749%2889%2990093-2
Elsevier BV
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