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Abnormal globulins in some neoplastic diseases

Clinica Chimica Acta, ISSN: 0009-8981, Vol: 1, Issue: 1, Page: 16-22
1956
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Article Description

Abnormal globulins were isolated from the blood sera of three patients with neoplastic diseases. The globulins had the electrophoretic mobilities of the γ-globulins but they differed from the latter in solubility, sedimentation, viscosity, and optical rotation. All of the specimens had in common high intrinsic viscosity and low optical activity, but their sedimentation constants were different. The axial ratios were found to be approximately 10 : 1 for these globulins. The globulins are denatured easily in weakly acidic and in strongly alkaline solutions. An explanation of the phenomena was proposed.

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