PlumX Metrics
Embed PlumX Metrics

Transcriptional regulation of type X collagen during chondrocyte maturation

Developmental Biology, ISSN: 0012-1606, Vol: 133, Issue: 2, Page: 613-616
1989
  • 40
    Citations
  • 0
    Usage
  • 6
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

Article Description

The 18-day embryonic chick sternum expresses type X collagen only in the cephalic, presumptive mineralization zone which consists primarily of hypertrophic chondrocytes. The smaller chondrocytes of the caudal, permanent cartilaginous zone do not express this protein. Run-off transcriptions of nuclei isolated directly from cephalic and caudal 18-day embryonic sterna demonstrate that type X collagen is specifically transcribed by cells of the cephalic zone. In addition, type X mRNA is localized to the cephalic zone as detected by in situ hybridization. The results suggest that the cell-specific expression of the type X collagen gene is due entirely to transcriptional regulation.

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know