Diacylglycerol in the synergy of bradykinin and thrombin stimulation of prostaglandin synthesis
European Journal of Pharmacology, ISSN: 0014-2999, Vol: 168, Issue: 1, Page: 39-42
1989
- 8Citations
- 3Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations8
- Citation Indexes8
- CrossRef5
- Captures3
- Readers3
Article Description
Simultaneous addition of bradykinin and thrombin to 3T3 fibroblasts for 5 min resulted in less than additive stimulation of prostaglandin E 2 synthesis. However, if cells were stimulated with either agonist alone, then the other added 15 min later, prostaglandin E 2 synthesis was synergistically enhanced. In contrast, if either agonist was added, then prostaglandin E 2 synthesis in response to the same agonist assessed 15 min later, synthesis was markedly reduced. Bradykinin and thrombin caused increased diacylglycerol accumulation in the cells, and addition of the diacylglycerol kinase inhibitor R59022 dramatically increased the effects of sequential addition of the agonists. These results suggest that diacylglycerol generated in response to activation of one receptor amplifies the effects of activation of other receptors.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/0014299989906304; http://dx.doi.org/10.1016/0014-2999(89)90630-4; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0024428965&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/2555202; https://linkinghub.elsevier.com/retrieve/pii/0014299989906304; http://dx.doi.org/10.1016/0014-2999%2889%2990630-4; https://dx.doi.org/10.1016/0014-2999%2889%2990630-4
Elsevier BV
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