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Effect of bradykinin on NaCl transport in the medullary thick ascending limb of the rat

European Journal of Pharmacology, ISSN: 0014-2999, Vol: 287, Issue: 1, Page: 101-104
1995
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Article Description

The aim of the present study was to determine whether bradykinin affects NaCl reabsorption in the medullary thick ascending limb of the loop of Henle. At 10 −8 M, bradykinin significantly inhibited Cl − transport in the in vitro microperfused rat medullary thick ascending limb by 67% ( P < 0.01). This inhibitory effect could be totally prevented by preincubating tubules with the bradykinin B 2 receptor antagonist N α-adamantaneacetyl- d -Arg-[Hyp 3,Thi 5,8, d -Phe 7 ]bradykinin (10 −6 M). In contrast, the bradykinin B 1 receptor agonist des-Arg 9 bradykinin (10 −6 M) had no effect on Cl − transport. Bradykinin caused transient increases in intracellular Ca 2+ concentration, which could be blocked by the bradykinin B 2 receptor antagonist, but could not be reproduced with the bradykinin B 1 receptor agonist. These data suggest that the natriuretic and diuretic effect of bradykinin in vivo is due, at least in part, to a bradykinin B 2 receptor-mediated inhibition of NaCl reabsorption in the medullary thick ascending limb of the loop of Henle.

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