Oxidant injury to hepatic mitochondria in patients with Wilson's disease and Bedlington terriers with copper toxicosis
Gastroenterology, ISSN: 0016-5085, Vol: 107, Issue: 6, Page: 1788-1798
1994
- 191Citations
- 45Captures
Metric Options: Counts1 Year3 YearSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations191
- Citation Indexes189
- 189
- CrossRef151
- Clinical Citations2
- PubMed Guidelines2
- Captures45
- Readers45
- 45
Article Description
Background/Aims: Copper overload leads to liver injury in humans with Wilson's disease and in Bedlington terriers with copper toxicosis; however, the mechanisms of liver injury are poorly understood. This study was undertaken to determine if oxidant (free radical) damage to hepatic mitochondria is involved in naturally occurring copper toxicosis. Methods: Fresh liver samples were obtained at the time of liver transplantation from 3 patients with Wilson's disease, 8 with cholestatic liver disease, and 5 with noncholestatic liver disease and from 8 control livers. Fresh liver was also obtained by open liver biopsy from 4 copper-overloaded and 4 normal Bedlington terriers and from 8 control dogs. Hepatic mitochondria and microsomes (humans only) were isolated, and lipid peroxidation was measured by lipid-conjugated dienes and thiobarbituric acid-reacting substances. In humans, liver α-tocopherol content was measured. Results: Lipid peroxidation and copper content were significantly increased ( P < 0.05) in mitochondria from patients with Wilson's disease and copper-overloaded Bedlington terriers. More modest increases in lipid peroxidation were present in microsomes from patients with Wilson's disease. Mitochondrial copper concentrations correlated strongly with the severity of mitochondrial lipid peroxidation. Hepatic α-tocopherol content was decreased significantly in Wilson's disease liver. Conclusions: These data suggest that the hepatic mitochondrion is an important target in hepatic copper toxicity and that oxidant damage to the liver may be involved in the pathogenesis of copper-induced injury.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/0016508594908222; http://dx.doi.org/10.1016/0016-5085(94)90822-2; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0027943858&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/7958693; http://linkinghub.elsevier.com/retrieve/pii/0016508594908222; http://dx.doi.org/10.1016/0016-5085%2894%2990822-2; https://dx.doi.org/10.1016/0016-5085%2894%2990822-2
Elsevier BV
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know