Evidence for the detrimental role of proteolysis during liver preservation in humans
Gastroenterology, ISSN: 0016-5085, Vol: 108, Issue: 5, Page: 1510-1516
1995
- 72Citations
- 13Captures
Metric Options: Counts1 Year3 YearSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations72
- Citation Indexes72
- 72
- CrossRef67
- Captures13
- Readers13
- 13
Article Description
Background/Aims Proteolysis may persist in the liver aliograft during cold storage. The aim of this study was to determine the significance of proteolysis within liver allografts stored at 4°C in University of Wisconsin preservation fluid. Methods Thirty recipients of 32 liver allografts were studied prospectively. Amino acid content of the preservation fluid was analyzed at the end of cold storage and was correlated to graft and patient outcome after transplantation. Results Analysis of the preservation fluid showed the presence of free amino acids, the profile of which was different from that of stored liver parenchyma. Concentrations of amino acids (alanine, cysteine, leucine, isoleucine, methionine, lysine, ornithine, and threonine) and transaminases (alanine aminotransferase and aspartate aminotransferase) in the preservation fluid correlated with the duration of cold ischemia. Indexes of graft dysfunction (serum alanine aminotransferase and aspartate aminotransferase peaks and prothrombin rate) correlated with concentrations of cysteine, alanine, isoleucine, leucine, methionine, lysine, ornithine, and threonine, whereas enzyme concentrations in the fluid were not predictive of graft dysfunction. Conclusions These data suggest that liver proteolysis occurs during cold storage and may have a detrimental effect on the outcome after transplantation. The measurement of the amino acids in the preservation fluid at the end of the cold storage period could help to identify the most severely damaged organs.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/0016508595907017; http://dx.doi.org/10.1016/0016-5085(95)90701-7; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0028931349&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/7729644; https://linkinghub.elsevier.com/retrieve/pii/0016508595907017; http://dx.doi.org/10.1016/0016-5085%2895%2990701-7; https://dx.doi.org/10.1016/0016-5085%2895%2990701-7
Elsevier BV
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know