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The distribution of apo C-II and apo C-III in very low density lipoproteins of normal and type iv subjects

Atherosclerosis, ISSN: 0021-9150, Vol: 35, Issue: 4, Page: 419-424
1980
  • 31
    Citations
  • 0
    Usage
  • 3
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    31
    • Citation Indexes
      31
  • Captures
    3

Article Description

The apoC-II/apoC-III ratio and the distribution of C apoproteins as percentage of the total protein in VLDL obtained from normolipidemic and type IV patients was studied by analytical isoelectrofocusing. While the percentage concentration of apoC-III was unchanged that of apoC-II was 9.2% of total protein in normal VLDL and only 7.4% in type IV VLDL ( P < 0.05). The apoC-II/apoC-III ratio significantly decreased in type IV patients. The analysis of VLDL subfractions obtained by density gradient ultracentrifugation gave essentially the same results. These data confirm the decrease of apoC-II as % of the protein in type IV VLDL and suggest that the decrease of the apoC-II/apoC-III ratio in type IV patients is related only to the decreased content of apoC-II. Whether the reduced apoC-II percentage amount or the decreased apoC-II/apoC-III ratio are related to the hypertriglyceridemia in type IV subjects is still unclear.

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