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Segments from modified human fibrinogen

Journal of Molecular Biology, ISSN: 0022-2836, Vol: 143, Issue: 3, Page: 329-334
1980
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Article Description

This paper describes an unusual segment aggregate of modified human fibrinogen that reveals where the molecules begin and end. Electron micrographs of these arrays display a strikingly simple band pattern with a repeat of about 400 Å, or nearly twice that of fibrin fibers. Preliminary analysis indicates that the molecules are packed with their ends in register, unlike the packing inferred for fibrin and for microcrystals and crystals of fibrinogen. The staining of the segments indicates that the mass distribution of fibrinogen is similar but not identical to the Hall & Slayter (1959) model for the molecule.

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