In vitro effects of toxaphene on mitochondrial calcium ATPase and calcium uptake in selected rat tissues
Life Sciences, ISSN: 0024-3205, Vol: 36, Issue: 5, Page: 427-433
1985
- 11Citations
- 1Mentions
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Metrics Details
- Citations11
- Citation Indexes8
- CrossRef8
- Policy Citations3
- Policy Citation3
- Mentions1
- References1
- Wikipedia1
Article Description
In vitro effects of toxaphene on Ca 2+ -ATPase activity and 45 Ca 2+ -uptake were studied in mitochondrial fractions of heart, kidney and liver tissues of rat. Mitochondrial fractions were prepared by the conventional centrifugation method. Ca 2+ -ATPase activity was determined by measuring the inorganic phosphate liberated during ATP hydrolysis. Toxaphene inhibited Ca 2+ -ATPase in a concentration dependent manner in all the three tissues. Substrate activation kinetics, with heart, kidney and liver tissue fractions, revealed that toxaphene inhibited Ca 2+ -ATPase activity non-competetively by decreasing the maximum velocity of the enzyme without affecting the enzyme-substrate affinity. Toxaphene also inhibited mitochondrial 45 Ca 2+ -uptake in the three selected tissues in a concentration dependent manner. These results indicate that toxaphene is an inhibitor of mitochondrial Ca 2+ -ATPase and calcium transport in heart, kidney and liver tissues of rat.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/0024320585902541; http://dx.doi.org/10.1016/0024-3205(85)90254-1; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0022006481&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/3155819; https://linkinghub.elsevier.com/retrieve/pii/0024320585902541; http://dx.doi.org/10.1016/0024-3205%2885%2990254-1; https://dx.doi.org/10.1016/0024-3205%2885%2990254-1
Elsevier BV
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