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Effect of phenobarbital on metabolism of polyphosphoinositides of rat brain synaptosomes

Life Sciences, ISSN: 0024-3205, Vol: 41, Issue: 18, Page: 2121-2126
1987
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  • Citations
    13
    • Citation Indexes
      13

Article Description

Synthesis and degradation of polyphosphoinositides in a rat brain synaptosome preparation were depressed by phenobarbital. Phosphatidylinositol-4-phosphate kinase (PIP-kinase), the enzyme which synthesizes phosphatidylinositol-4, 5-bisphosphate (PIP 2 ) was most strongly affected (50% inhibition at 3 mM phenobarbital); phosphatidylinositol (PI-kinase) followed (50% at 15 mM). The phosphoesterases were less sensitive: PIP-monoesterase (50% at 39 mM), PIP 2 -monoesterase (at 47 mM), and, least inhibited, PIP-diesterase (50% at 65 mM) and PIP 2 -diesterase (at 68 mM). Phenobarbital by inhibiting PIP-kinase may reduce the membrane concentration of PIP 2 and thus dampen the stimulus-response which leads to the hydrolysis of PIP 2 and the formation of the second messenger, inositol-1,4,5-triphosphate (IP 3 ), involved in mobilization of intracellular Ca 2+.

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