Effect of phenobarbital on metabolism of polyphosphoinositides of rat brain synaptosomes
Life Sciences, ISSN: 0024-3205, Vol: 41, Issue: 18, Page: 2121-2126
1987
- 13Citations
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Metrics Details
- Citations13
- Citation Indexes13
- 13
- CrossRef10
Article Description
Synthesis and degradation of polyphosphoinositides in a rat brain synaptosome preparation were depressed by phenobarbital. Phosphatidylinositol-4-phosphate kinase (PIP-kinase), the enzyme which synthesizes phosphatidylinositol-4, 5-bisphosphate (PIP 2 ) was most strongly affected (50% inhibition at 3 mM phenobarbital); phosphatidylinositol (PI-kinase) followed (50% at 15 mM). The phosphoesterases were less sensitive: PIP-monoesterase (50% at 39 mM), PIP 2 -monoesterase (at 47 mM), and, least inhibited, PIP-diesterase (50% at 65 mM) and PIP 2 -diesterase (at 68 mM). Phenobarbital by inhibiting PIP-kinase may reduce the membrane concentration of PIP 2 and thus dampen the stimulus-response which leads to the hydrolysis of PIP 2 and the formation of the second messenger, inositol-1,4,5-triphosphate (IP 3 ), involved in mobilization of intracellular Ca 2+.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/0024320587905303; http://dx.doi.org/10.1016/0024-3205(87)90530-3; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0023611718&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/2823040; https://linkinghub.elsevier.com/retrieve/pii/0024320587905303; http://dx.doi.org/10.1016/0024-3205%2887%2990530-3; https://dx.doi.org/10.1016/0024-3205%2887%2990530-3
Elsevier BV
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