β-endorphin in brain limbic structures as neurochemical correlate of psychic dependence on drugs
Life Sciences, ISSN: 0024-3205, Vol: 44, Issue: 16, Page: 1133-1140
1989
- 61Citations
- 3Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations61
- Citation Indexes61
- 61
- CrossRef50
- Captures3
- Readers3
Article Description
The significance of β-endorphin for drug dependence was explored by measuring the levels of β-endorphin-immunoreactivity (βE-IR) in plasma and parts of pituitary and brain of rats self-administering heroin or cocaine as compared to animals offered saline. Rats that had intravenously self-administrated heroin for 5 consecutive daily sessions of 6 h, and were decapitated immediately after the last session, showed a decreased concentration of βE-IR in the anterior lobe (AL) of the pituitary while rats that had taken cocaine showed a decreased concentration of βE-IR in the septum. Rats that had self-administered heroin or cocaine and were decapitated 18 h after the last session, showed an increased concentration of βE-IR in plasma and decreased concentrations in the AL of the pituitary and in specific areas of the brain limbic system, i.e. nucleus accumbens, septum, hippocampus and rostral striatum. The finding that self-administration of both the opiate heroin, including psychic and physical dependence, and the non-opiate cocaine, including psychic but not physical dependence, is accompanied by similar changes in βE-IR concentrations particularly in limbic brain structures, and that these effects are present 18 h but not immediately after the last session, suggests that βE and related peptides in limbic brain regions may represent a neurochemical correlate for psychic dependence on drugs.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/002432058990341X; http://dx.doi.org/10.1016/0024-3205(89)90341-x; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0024383740&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/2523016; https://linkinghub.elsevier.com/retrieve/pii/002432058990341X; http://linkinghub.elsevier.com/retrieve/pii/002432058990341X; http://api.elsevier.com/content/article/PII:002432058990341X?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:002432058990341X?httpAccept=text/plain; http://dx.doi.org/10.1016/0024-3205%2889%2990341-x; https://dx.doi.org/10.1016/0024-3205%2889%2990341-x
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