Altered oxidation and signal transduction systems in fibroblasts from Alzheimer patients
Life Sciences, ISSN: 0024-3205, Vol: 59, Issue: 5, Page: 477-489
1996
- 57Citations
- 27Captures
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations57
- Citation Indexes57
- 57
- CrossRef44
- Captures27
- Readers27
- 27
Article Description
Abnormalities in calcium regulation, amyloid-β-protein (Aβ) production and oxidative metabolism have been implicated in Alzheimer's disease (AD). The use of cultured fibroblasts complement post-mortem and genetic approaches in clarifying the interaction of these processes and the underlying mechanism for the changes in AD. Definition of gene defects in particular Alzheimer families (FAD) permits elucidation of the role of those genetic abnormalities in altered signal transduction in cell lines from those families. Abnormalities in calcium regulation, ion channels, cyclic AMP, the phosphatidylinositide cascade and oxidative metabolism are well documented in fibroblasts from patients with primary genetic defects in the presenilins. Recent studies in AD fibroblasts that demonstrate abnormal secretion of Aβ, a protein known to form the characteristic extracellular amyloid deposits in AD brain, further supports the use of these cells in AD research. Comparison of changes in calcium signaling, mitochondrial oxidation and Aβ production in these cells suggests that changes in signal transduction including calcium may be a more consistent observation than altered Aβ production in fibroblasts from some FAD families. An understanding of these abnormalities in fibroblasts may provide further insights into the pathophysiology of AD, new diagnostic measures and perhaps innovative therapeutic approaches.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/002432059600327X; http://dx.doi.org/10.1016/0024-3205(96)00327-x; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0030567762&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/8761336; http://linkinghub.elsevier.com/retrieve/pii/002432059600327X; http://api.elsevier.com/content/article/PII:002432059600327X?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:002432059600327X?httpAccept=text/plain; https://linkinghub.elsevier.com/retrieve/pii/002432059600327X; http://dx.doi.org/10.1016/0024-3205%2896%2900327-x; https://research-repository.uwa.edu.au/en/publications/42ef3a85-7abf-46aa-918a-ae8188f6dbf3; https://research-repository.uwa.edu.au/en/publications/altered-oxidation-and-signal-transduction-systems-in-fibroblasts-; http://research-repository.uwa.edu.au/en/publications/altered-oxidation-and-signal-transduction-systems-in-fibroblasts-from-alzheimer-patients(42ef3a85-7abf-46aa-918a-ae8188f6dbf3).html; https://research-repository.uwa.edu.au/en/publications/altered-oxidation-and-signal-transduction-systems-in-fibroblasts-from-alzheimer-patients(42ef3a85-7abf-46aa-918a-ae8188f6dbf3).html
Elsevier BV
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know