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Effect of oxandrolone on plasma lipids and lipoproteins of patients with disorders of lipid metabolism

Metabolism, ISSN: 0026-0495, Vol: 17, Issue: 5, Page: 400-410
1968
  • 24
    Citations
  • 0
    Usage
  • 4
    Captures
  • 1
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    24
  • Captures
    4
  • Mentions
    1
    • References
      1
      • 1

Article Description

The effect of oxandrolone (17 β-hydroxy-17α-methyl-2-oxa-5α-androstan-3-one) on plasma lipids, lipoproteins, proteins and glycoproteins has been studied in subjects with primary disorders of lipid metabolism. The effect of this steroid on plasma lipids was highly selective in that it produced profound lowering of all plasma lipids only when the lipid disorder was associated with carbohydrate-induced hypertriglyceridemia (hyper-pre-β-lipoprotenemia). Subjects with familial hypercholesterolemia (hyper-β-lipoproteinemia) showed either no change or elevations of plasma lipids. A patient with fat-induced hypertriglyceridemia (hyperchylomicronemia) showed further elevations in plasma triglyceride levels with administration of the compound. The steroid produced significant increases in α 2 -globulins and α 2 -glycoproteins. A conceptual scheme is presented which correlates the plasma lipid and glycoprotein findings with the response to the drug.

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