Effect of oxandrolone on plasma lipids and lipoproteins of patients with disorders of lipid metabolism
Metabolism, ISSN: 0026-0495, Vol: 17, Issue: 5, Page: 400-410
1968
- 24Citations
- 4Captures
- 1Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations24
- Citation Indexes23
- CrossRef23
- 16
- Policy Citations1
- 1
- Captures4
- Readers4
- Mentions1
- References1
- 1
Article Description
The effect of oxandrolone (17 β-hydroxy-17α-methyl-2-oxa-5α-androstan-3-one) on plasma lipids, lipoproteins, proteins and glycoproteins has been studied in subjects with primary disorders of lipid metabolism. The effect of this steroid on plasma lipids was highly selective in that it produced profound lowering of all plasma lipids only when the lipid disorder was associated with carbohydrate-induced hypertriglyceridemia (hyper-pre-β-lipoprotenemia). Subjects with familial hypercholesterolemia (hyper-β-lipoproteinemia) showed either no change or elevations of plasma lipids. A patient with fat-induced hypertriglyceridemia (hyperchylomicronemia) showed further elevations in plasma triglyceride levels with administration of the compound. The steroid produced significant increases in α 2 -globulins and α 2 -glycoproteins. A conceptual scheme is presented which correlates the plasma lipid and glycoprotein findings with the response to the drug.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/0026049568900620; http://dx.doi.org/10.1016/0026-0495(68)90062-0; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0014289234&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/5648208; https://linkinghub.elsevier.com/retrieve/pii/0026049568900620; http://dx.doi.org/10.1016/0026-0495%2868%2990062-0; https://dx.doi.org/10.1016/0026-0495%2868%2990062-0
Elsevier BV
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