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The influence of multiple mutagenic treatments on the occurrence of 6-thioguanine-resistant mutants in dividing V79 cells

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, ISSN: 0027-5107, Vol: 159, Issue: 1, Page: 91-97
1986
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Article Description

Repeated treatments of dividing Chinese hamster V79 cells with ultraviolet radiation or a simple monofunctional alkylating agent (methyl methanesulphonate, N -methyl- N ′-nitr- N -nitrosoguanidine or N -methyl- N -nitrosourea) were studied with regard to the pattern of cumulative increase of 6-thioguanine-resistant mutants in the surviving population. There were 5–10 divisions of surviving cells between two successive treatments. Repeated treatments with different agents produced different effects. The observed results indicating either a higher or lower than additive effect of single doses may be explained by induced repair process.

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