Liquid holding increases mutation induction by formaldehyde and some other cross-linking agents in Escherichia coli K12
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, ISSN: 0027-5107, Vol: 210, Issue: 2, Page: 255-261
1989
- 15Citations
- 3Captures
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Metrics Details
- Citations15
- Citation Indexes13
- CrossRef13
- Policy Citations2
- Policy Citation2
- Captures3
- Readers3
Article Description
The induction by some cross-linking agents of forward mutations leading to nalidixic acid resistance in Escherichia coli K12/343/113 was considerably enhanced when a 24-h period of liquid holding was interpolated between treatment and growth phase. Liquid holding increased the mutagenic effectiveness of nor-nitrogen mustard (NNM) 28-fold, of phosphoramide mustar (PAM) 10-fold, and of tris-ethylen-eimino)-phosphineoxide (TEPA), tris(chloroethyl)amine (TCEA) and chloracetaldehyde (CAA) 3-fold, over the complete concentration range. By contrast, the activities of cisplatin (CDDP), transplatin (TDDP) and chloracetamide- N -metholol (CAM) were slightly decreased after liquid holding. Liquid holding did not measurably influence the mutagenicity of formadehyde at low concentrations, whereas at higher concentrations an 8-fold increase was observed.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/0027510789900869; http://dx.doi.org/10.1016/0027-5107(89)90086-9; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0024543243&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/2643024; https://linkinghub.elsevier.com/retrieve/pii/0027510789900869; http://dx.doi.org/10.1016/0027-5107%2889%2990086-9; https://dx.doi.org/10.1016/0027-5107%2889%2990086-9
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