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Liquid holding increases mutation induction by formaldehyde and some other cross-linking agents in Escherichia coli K12

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, ISSN: 0027-5107, Vol: 210, Issue: 2, Page: 255-261
1989
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The induction by some cross-linking agents of forward mutations leading to nalidixic acid resistance in Escherichia coli K12/343/113 was considerably enhanced when a 24-h period of liquid holding was interpolated between treatment and growth phase. Liquid holding increased the mutagenic effectiveness of nor-nitrogen mustard (NNM) 28-fold, of phosphoramide mustar (PAM) 10-fold, and of tris-ethylen-eimino)-phosphineoxide (TEPA), tris(chloroethyl)amine (TCEA) and chloracetaldehyde (CAA) 3-fold, over the complete concentration range. By contrast, the activities of cisplatin (CDDP), transplatin (TDDP) and chloracetamide- N -metholol (CAM) were slightly decreased after liquid holding. Liquid holding did not measurably influence the mutagenicity of formadehyde at low concentrations, whereas at higher concentrations an 8-fold increase was observed.

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