Mechanisms of spontaneous mutation in DNA repair-proficient Escherichia coli
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, ISSN: 0027-5107, Vol: 250, Issue: 1, Page: 55-71
1991
- 72Citations
- 11Captures
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Metrics Details
- Citations72
- Citation Indexes72
- 72
- CrossRef49
- Captures11
- Readers11
- 11
Article Description
This paper describes the DNA sequence analysis of 729 independent spontaneous lacI− mutation This total is comprised of 478 novel mutations and 251 previously described events, and therefore should allow a more comprehensive view of spontaneous mutation in Escherichia coli. The spectrum is dominated by a hotspot (71% of all events). Mutations at this site consist of related addition and deletion events involving a number of repetitive sequences. Here we discuss how the frequency and proportion of these events vary in different DNA repair-deficient genetic backgrounds. The distribution of non-hotspot events includes base substitutions (38%), deletions (35%), frameshifts (14%), duplications (4%) and insertion elements (4%). G:C → A:T events dominate among base substitutions, while G:C → C:G events are the least common; the remaining types of base substitution are equally represented. Among deletions, a significant number do not display repeated sequences at their endpoints (26/72). However, almost all multiply recovered events (15/17) possess repeated sequences capable of accounting for the deletion endpoints. Similarily, over of all duplications recovered (5/7) display repeated endpoints. Single-base frameshifts are equally divided between A:T and G:C sites, in each case (−) 1 events occur 3-fold more frequently that (+)1 events. A comparative analysis of each mutational class recovered to lacI− spectra available in a variety of DNA repair/metabolism-deficient strains is presented here in an attempt to assess possible contributions from chemical, physical and enzymic sources of damage.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/002751079190162H; http://dx.doi.org/10.1016/0027-5107(91)90162-h; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0025858529&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/1944363; https://linkinghub.elsevier.com/retrieve/pii/002751079190162H; http://linkinghub.elsevier.com/retrieve/pii/002751079190162H; http://api.elsevier.com/content/article/PII:002751079190162H?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:002751079190162H?httpAccept=text/plain; http://dx.doi.org/10.1016/0027-5107%2891%2990162-h; https://dx.doi.org/10.1016/0027-5107%2891%2990162-h
Elsevier BV
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