Properties of two benzodiazepine binding sites in spinal cord
Neuropharmacology, ISSN: 0028-3908, Vol: 22, Issue: 1, Page: 115-118
1983
- 16Citations
- 3Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations16
- Citation Indexes16
- 16
- CrossRef15
- Captures3
- Readers3
Article Description
Two types of benzodiazepine receptors were demonstrated in spinal cord. Binding to one of these sites (neuronal) was sensitive to the centrally active benzodiazepine, clonazepam, and binding was enhanced both by chloride and GABA. The second site was sensitive to 7-chloro-1,3-dihydro-1-methyl-5-(p-chlorophenyl) 2H-1,4-benzodiazepine-2-one (R05-4864) and thus is similar to the site characteristic of non-neuronal tissue. Binding to the neuronal site was inhibited by the putative glycine antagonist, strychnine, both in spinal cord and brain. This inhibition may account for the reported anti-GABAergic properties of strychnine and does not appear to be related to the glycine receptor.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/0028390883902691; http://dx.doi.org/10.1016/0028-3908(83)90269-1; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0020699265&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/6302542; https://linkinghub.elsevier.com/retrieve/pii/0028390883902691; http://dx.doi.org/10.1016/0028-3908%2883%2990269-1; https://dx.doi.org/10.1016/0028-3908%2883%2990269-1
Elsevier BV
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