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Interspecies variations in plasma half-life of ampicillin, amoxycillin, sulphadimidine and sulphacetamide related to variations in body mass

Research in Veterinary Science, ISSN: 0034-5288, Vol: 53, Issue: 2, Page: 160-164
1992
  • 15
    Citations
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  • 9
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Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    15
    • Citation Indexes
      15
  • Captures
    9

Article Description

The relationships between the half-lives during the elimination phase ( t12 minutes) of ampicillin, amoxycillin, sulphadimidine and sulphacetamide and body mass (W, kg) between species of mammals and birds were examined using data from the authors' experiments and collected from the literature. Linear regression of the log half-lives of ampicillin, amoxycillin and sulphadimidine following intravenous injection on the log body mass for a variety of species of mammals and birds revealed significant correlations (r = 0·7709, n = 8, r = 0·7712, n = 8, r = 0·7749, n = 10). The interspecies relationships were described by the allometric equations t12 = 31·3 W 0·16, t12 = 32·7 W 0·12 and t12 = 129·2 W 0·28, respectively. These equations may be of value for estimating dose intervals in species for which no relevant pharmacokinetic data are available.

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