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Alveolar-arterial equilibration in the lung of sheep

Respiration Physiology, ISSN: 0034-5687, Vol: 55, Issue: 2, Page: 205-221
1984
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In order to compare the efficiency of sheep lung with that of dog, gaseous exchange in hypoxia (F I O2 0.12–0.13) with and without CO in the inspired air (F I CO 0.001) was measured in 12 sheep (mean body weight = 30.4 kg) under pentothal anesthesia and artificial ventilation. Alveolar-arterial pressure difference of O 2, % venous admixture and amount of V A /Q inhomogeneity were found to be substantially larger than in dog. Steady-state pulmonary diffusing capacity estimates, computed by three different procedures were, both for O 2 and for CO, about 40% smaller than in dog. The Dt O2 /Dl CO ratio were not significantly different from those determined on dog data; thus the presumed benefecial effect of sheep small erythrocytes on O 2 transfer could not be demonstrated. Because its DL O2 /M O2 ratio is lower than that of dog, sheep appears to be more adequate than dog as a model for human alveolar-arterial gas exchange.

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