Biological characterization of paired human immunodeficiency virus type 1 isolates from blood and cerebrospinal fluid
Virology, ISSN: 0042-6822, Vol: 173, Issue: 1, Page: 178-187
1989
- 36Citations
- 9Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations36
- Citation Indexes36
- CrossRef36
- 31
- Captures9
- Readers9
Article Description
Virus has been isolated from the blood and cerebrospinal fluid (CSF) of eight subjects with varying severity of human immunodeficiency virus type 1 (HIV-1) infection and from the frontal lobe of one patient with AIDS. The five patients with AIDS-related complex (ARC) and AIDS also showed neurological/psychiatric complications. With the exception of one isolate from the CSF of an asymptomatic carrier, all isolates replicated in peripheral blood mononuclear cells and monocytes after cell-free transmission. Isolates obtained from the blood of patients in late stages of HIV infection replicated in 3 (of 4) cases in H9 cells, whereas none of the blood isolates from patients in the early stages did so. The capacity of CSF isolates to replicate in H9 cells was low (only 2 of 12). Paired virus isolates from blood and CSF of the same patient could be distinguished by their replicative capacity in different cell lines, type of cytopathic effect, and protein profile as tested by radioimmunoprecipitation. The results indicate that variant viruses with distinct biological characteristics maybe isolated from the blood and CSF of the same patient.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/004268228990233X; http://dx.doi.org/10.1016/0042-6822(89)90233-x; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0024443820&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/2683359; http://linkinghub.elsevier.com/retrieve/pii/004268228990233X; http://api.elsevier.com/content/article/PII:004268228990233X?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:004268228990233X?httpAccept=text/plain; https://linkinghub.elsevier.com/retrieve/pii/004268228990233X; http://dx.doi.org/10.1016/0042-6822%2889%2990233-x; https://dx.doi.org/10.1016/0042-6822%2889%2990233-x
Elsevier BV
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