Effect of age on axoplasmic transport of cholinesterase in rat sciatic nerves
Mechanisms of Ageing and Development, ISSN: 0047-6374, Vol: 10, Issue: 3, Page: 241-248
1979
- 62Citations
- 14Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations62
- Citation Indexes62
- 62
- CrossRef61
- Captures14
- Readers14
- 14
Article Description
Senile muscle atrophy has been attributed to an impaired ability of old nerves to transport trophic factors. To evaluate the effect of age on axoplasmic transport, we measured the accumulation of cholinesterase activity above a ligature around sciatic nerves of young (7–8 months), middle-aged (19–20 months), and old (31–32 months) male rats. Protein content and cholinesterase activity per mm of nerve were higher in middle-aged and old than in young nerves. However, accumulation of cholinesterase activity was significantly lower by middle age and was strikingly reduced by old age. This large reduction in axoplasmic transport appeared to result from factors other than axonal loss. A model in which old nerves have an increased number of temporary focal blockages of particle movement in axoplasmic channels is proposed to explain the decreased transport.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/0047637479900381; http://dx.doi.org/10.1016/0047-6374(79)90038-1; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0018761621&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/88552; https://linkinghub.elsevier.com/retrieve/pii/0047637479900381; http://dx.doi.org/10.1016/0047-6374%2879%2990038-1; https://dx.doi.org/10.1016/0047-6374%2879%2990038-1
Elsevier BV
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