Induction of tumor cytostatic macrophages by 12- O -tetradecanoyl phorbol-13-acetate (TPA)
Clinical Immunology and Immunopathology, ISSN: 0090-1229, Vol: 17, Issue: 4, Page: 617-628
1980
- 14Citations
Metric Options: Counts1 Year3 YearSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations14
- Citation Indexes14
- CrossRef14
- 13
Article Description
Treatment of unstimulated peritoneal macrophages of C57Bl/6 mice with TPA rapidly converted them to tumor cytostatic effector cells as determined by an inhibition of the growth of EL4 tumor cells in vitro. The effective TPA concentrations were 10 −8 to 10 −7 M. Induction of tumor cytostatic macrophages occurred as early as 1 to 3 hr after exposure to TPA and the tumor cytostatic activity persisted up to 48 hr. Generation of antitumor active macrophages was accompanied by an enhancement of other functional and metabolic changes such as pinocytosis, activity of the hexose monophosphate shunt, incorporation of glucosamine, and release of prostaglandin E. The data support the notion that TPA may be a valuable tool to study biochemical mechanisms involved in the generation of stimulated and activated macrophages.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/0090122980901579; http://dx.doi.org/10.1016/0090-1229(80)90157-9; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0019164907&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/7438572; https://linkinghub.elsevier.com/retrieve/pii/0090122980901579; http://dx.doi.org/10.1016/0090-1229%2880%2990157-9; https://dx.doi.org/10.1016/0090-1229%2880%2990157-9
Elsevier BV
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