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Induction of tumor cytostatic macrophages by 12- O -tetradecanoyl phorbol-13-acetate (TPA)

Clinical Immunology and Immunopathology, ISSN: 0090-1229, Vol: 17, Issue: 4, Page: 617-628
1980
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Article Description

Treatment of unstimulated peritoneal macrophages of C57Bl/6 mice with TPA rapidly converted them to tumor cytostatic effector cells as determined by an inhibition of the growth of EL4 tumor cells in vitro. The effective TPA concentrations were 10 −8 to 10 −7 M. Induction of tumor cytostatic macrophages occurred as early as 1 to 3 hr after exposure to TPA and the tumor cytostatic activity persisted up to 48 hr. Generation of antitumor active macrophages was accompanied by an enhancement of other functional and metabolic changes such as pinocytosis, activity of the hexose monophosphate shunt, incorporation of glucosamine, and release of prostaglandin E. The data support the notion that TPA may be a valuable tool to study biochemical mechanisms involved in the generation of stimulated and activated macrophages.

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