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Characterization of biological properties of synthetic and biological leukotriene B 3

Prostaglandins, ISSN: 0090-6980, Vol: 30, Issue: 6, Page: 981-988
1985
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Leukotriene B 3 was chemically synthesized and its ability to aggregate rat polymorphonuclear leukocytes (PMN) and to enhance chemokinesis of human leukocytes demonstrated. In both these assays the potency of synthetic leukotriene B 3 was marginally less than that of leukotriene B 4. Rat PMN incubated with leukotriene A 3 were very inefficient in the enzymatic conversion of this epoxide to leukotriene B 3. However, the leukotriene B 3 produced was able to aggregate rat PMN. These results suggest that unlike leukotriene B 5, the proinflammatory properties of leukotriene B 3 are similar to those of leukotriene A 4. However, since the enzymatic conversion of leukotriene A 3 to leukotriene B 3 is extremely poor it seems unlikely that leukotriene B 3 itself has any major role in vivo.

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