Contingent drug tolerance: Differential tolerance to the anticonvulsant, hypothermic, and ataxic effects of ethanol
Pharmacology Biochemistry and Behavior, ISSN: 0091-3057, Vol: 52, Issue: 3, Page: 531-539
1995
- 5Citations
- 3Captures
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations5
- Citation Indexes5
- CrossRef3
- Captures3
- Readers3
Article Description
The kindled-convulsion model of epilepsy was used to study contingent tolerance to ethanol's (1.5 g/kg; IP) anticonvulsant, hypothermic, and ataxic effects in adult male rats. In the present experiments, three groups of amygdala-kindled rats received a series of bidaily (one every 48 h) convulsive stimulations: one group received ethanol 1 h before each stimulation; one group received ethanol l h after each stimulation; and another group served as the saline control. Tolerance to ethanol's anticonvulsant effect (Experiments 1 and 2) was greatest in those rats that received ethanol before each convulsive stimulation; whereas, tolerance to ethanol's hypothermic (Experiments 1 and 2) and ataxic (Experiments 2) effects developed in both groups that received ethanol. These results were predicted on the basis of the drug-effect theory of drug tolerance: the theory that functional drug tolerance is an adaptation to the disruptive effects of drugs on concurrent patterns of neural activity, not to drug exposure per se.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/009130579500126H; http://dx.doi.org/10.1016/0091-3057(95)00126-h; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0029114357&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/8545470; https://linkinghub.elsevier.com/retrieve/pii/009130579500126H; http://linkinghub.elsevier.com/retrieve/pii/009130579500126H; http://api.elsevier.com/content/article/PII:009130579500126H?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:009130579500126H?httpAccept=text/plain; http://dx.doi.org/10.1016/0091-3057%2895%2900126-h; https://dx.doi.org/10.1016/0091-3057%2895%2900126-h
Elsevier BV
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