Influence of β-myrcene on sister-chromatid exchanges induced by mutagens in V79 and HTC cells
Mutation Research Letters, ISSN: 0165-7992, Vol: 264, Issue: 1, Page: 43-49
1991
- 41Citations
- 13Captures
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Metrics Details
- Citations41
- Citation Indexes38
- 38
- CrossRef31
- Policy Citations3
- Policy Citation3
- Captures13
- Readers13
- 13
Article Description
The influence of β-myrcene (MC) on sister-chromatid exchanges (SCE) in V79 cells induced by 4 S9 mixactivated indirect mutagens was studied. The mutagens used were cyclophosphamide (CP), benzo[ a ]pyrene (BP), aflatoxin B 1 (AFB) and 9,10-dimethyl-1,2-benz[ a ]amhracene (DMBA). MC effectively inhibited SCEs induced by CP and AFB in a dose-dependent manner, but it had no effect on SCE induction by BP and DMBA. MC also reduced CP-induced SCE frequencies in a hepatic tumor cell line (HTC). These cells are metabolically competent and activate CP into its biologically active metabolites. Our results support the suggestion that MC modulates the genotoxicity of indirect-acting mutagens by inhibiting certain forms of the cytochrome P-450 enzymes required for activation of premutagens like CP and AFB.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/0165799291900445; http://dx.doi.org/10.1016/0165-7992(91)90044-5; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0025816998&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/1908947; https://linkinghub.elsevier.com/retrieve/pii/0165799291900445; http://dx.doi.org/10.1016/0165-7992%2891%2990044-5; https://dx.doi.org/10.1016/0165-7992%2891%2990044-5
Elsevier BV
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