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Alkylacetylglycerophosphocholine stimulates Na + -Ca 2+ exchange, protein phosphorylation and polyphosphoinositide turnover in rat ileal plasmalemmal vesicles

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, ISSN: 0167-4889, Vol: 888, Issue: 3, Page: 306-315
1986
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Article Description

The novel ether phospholipid, 1- O -alkyl-2-acetyl- sn -glycero-3-phosphocholine (AGEPC), isometrically contracted helically cut rat ileal smooth muscle strips in a dose- and time-dependent manner. Utilizing an enriched plasma membrane vesicular preparation from rat ileal longitudinal smooth muscle, AGEPC specifically stimulated Na + -Ca 2+ exchange in a dose- and time-dependent manner. Concomitant with the AGEPC stimulation of Na + -dependent Ca 2+ influx in plasma membrane vesicles is an enhanced turnover of the polyphosphoinositides, an elevated concentration of phosphatidic acid and also an enhanced phosphorylation of an M r 40 000 plasmalemmal protein. The mechanisms by which AGEPC may regulate ileal plasmalemmal Ca 2+ flux and contractility are considered.

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