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Prostaglandin D 2 modulates sleep-related and noradrenaline-induced activity of preoptic and basal forebrain neurons in the rat

Neuroscience Research, ISSN: 0168-0102, Vol: 23, Issue: 3, Page: 257-268
1995
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Article Description

Prostaglandin D 2 (PGDZ) was applied by pressure through a multibarrel micropipette to sleep-related neurons in the preoptic and neighboring basal forebrain area in head-restrained unanesthetized rats. During wakefulness, PGD 2 excited six of 13 sleep-active neurons, inhibited seven of 13 waking-active neurons, and did not affect the remaining neurons. During slow-wave sleep (SWS), however, PGD 2 excited only three of 17 sleep-active neurons and inhibited two of 13 waking-active neurons. State-indifferent neurons, which lacked activity related to the sleep-waking state, were insensitive to PGDZ irrespective of wakefulness ( n = 24) and SWS ( n = 40). These results suggest that PGDZ promotes sleep by exciting sleep-active neurons and by inhibiting waking-active neurons. Furthermore, continuous administration of PGD 2 attenuated activity changes associated with wakefulness of five sleep-active and three waking-active neurons tested. Because we had suggested the involvement of preoptic noradrenaline (NA) in arousal, we examined possible modulatory effects of PGD 2 on NA-induced neuron responses. PGD 2 attenuated NA-induced inhibitory responses in four of six sleep-active neurons and in one of 10 state-indifferent neurons. PGDZ also attenuated NA-induced excitation in four waking-active neurons tested. Accordingly, the modulatory action of PGD 2 on sleep-related neurons is important in the mechanism of sleep.

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