Regulation of NMDA receptor subunit mRNA expression in the rat brain during postnatal development
Molecular Brain Research, ISSN: 0169-328X, Vol: 25, Issue: 3, Page: 209-216
1994
- 71Citations
- 19Captures
Metric Options: Counts1 Year3 YearSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations71
- Citation Indexes71
- 71
- CrossRef54
- Captures19
- Readers19
- 19
Article Description
Different NMDA receptor subunits have been recently cloned. The present paper describes the developmental profile of expression of the NR-1 subunit and three NR-2 subunits (A, B, C) in the rat central nervous system. A sensitive RNase protection assay was employed to determine simultaneously the mRNA levels of these receptor subunits. We found low levels of NR-1 mRNA (comprising all different splicing isoforms) in newborn rats with a progressive increase of its expression in the following 2–3 weeks. NR-2 subunits can be regarded as ‘modulatory’ since their expression can produce differences in the properties of NMDA receptors. More than one NR-2 subunits can be expressed in the same brain region. NR-2A and NR-2C are concomitantly expressed in the cerebellum and during development their mRNAs increase with a similar profile from low levels in P-8 rats to maximal expression in P-21 animals. NR-2A and NR-2B are concomitantly expressed in several brain regions with a different ontogenetic profile. In the hippocampus NR-2B mRNA increases rapidly during the first week of life as compared to the NR-2A subunits which at this time is expressed to low levels indicating that NR-2B will probably be dominant in determining the NMDA properties during the first period of life. Our data can provide a molecular correlate with properties of NMDA receptors such as voltage dependent Mg 2+ block and deactivation kinetics which undergo significant changes during development and have been shown to depend upon the NR-2 subunit co-expressed with the common NR-1 subunit in various brain regions.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/0169328X94901554; http://dx.doi.org/10.1016/0169-328x(94)90155-4; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0028049541&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/7808219; http://linkinghub.elsevier.com/retrieve/pii/0169328X94901554; http://api.elsevier.com/content/article/PII:0169328X94901554?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:0169328X94901554?httpAccept=text/plain; https://linkinghub.elsevier.com/retrieve/pii/0169328X94901554; http://dx.doi.org/10.1016/0169-328x%2894%2990155-4; https://dx.doi.org/10.1016/0169-328x%2894%2990155-4
Elsevier BV
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know