[ 125 I]Endothelin binding in rat cerebellum is increased following l -2-chloropropionic-acid-induced granule cell necrosis
Peptides, ISSN: 0196-9781, Vol: 16, Issue: 5, Page: 897-902
1995
- 10Citations
- 1Captures
Metric Options: CountsSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations10
- Citation Indexes10
- 10
- CrossRef8
- Captures1
- Readers1
Article Description
The systemic administration of l -2-chloropropionic acid ( l -CPA) to rats produced a marked depletion of cerebellar granule cells (> 80% of the total) when administered in a single oral dose of 750 or 250 mg/kg/day for 3 days. The nature of the l -CPA-induced neurotoxicity is currently unknown but it exhibits a number of features in common with excitatory amino acid-induced neuronal cell death. We observed an increase in [ 125 I]endothelin-1 (ET-1) binding in the cerebellar cortex, as measured by quantitative receptor autoradiography, which occurs at 48 h, but not 24 h, following the 750 mg/kg l -CPA dosing regimen. The increase in [ 125 I]ET-1 binding did not parallel the cellular damage and resultant astrocyte proliferation, as measured by GFAP immunoreactivity, which was primarily confined to the granular layer of the cerebellar cortex. The increased [ 125 I]ET-1 binding occurred in the molecular layer of the cerebellar cortex (controls 2.03 ± 0.26 fmol/mg tissue; l -CPA-treated 6.69 ± 0.45 fmol/mg tissue, n = 6; p < 0.01, Student's t -test) which appeared to contain astrocytic processes originating from the large increase in astrocyte number situated in the granular layer. Pretreatment of the rats with the irreversible NMDA receptor antagonist, MK-801, protected the cerebellar granule cells against the L-CPA neurotoxicity and also prevented the increase in [ 125 I]ET-1 binding in the cerebellar cortex. The increased [ 125 I]ET-1 binding in rat cerebellum appears to be linked to the reactive gliosis that occurs in association with neuronal cell injury.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/019697819500050T; http://dx.doi.org/10.1016/0196-9781(95)00050-t; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0028982628&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/7479332; https://linkinghub.elsevier.com/retrieve/pii/019697819500050T; http://linkinghub.elsevier.com/retrieve/pii/019697819500050T; http://api.elsevier.com/content/article/PII:019697819500050T?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:019697819500050T?httpAccept=text/plain; http://dx.doi.org/10.1016/0196-9781%2895%2900050-t; https://dx.doi.org/10.1016/0196-9781%2895%2900050-t
Elsevier BV
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know