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Subtypes of HLA-B27 detected by cytotoxic T lymphocytes and their role in self-recognition

Human Immunology, ISSN: 0198-8859, Vol: 5, Issue: 4, Page: 259-268
1982
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Metric Options:   Counts1 Year3 Year

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Article Description

In the present study cytotoxic T lymphocytes were generated in MLC of lymphocytes from two unrelated HLA-A, B, C-identical, B27-positive, but D/DR-different, individuals. These CTL were shown to detect subtypes of HLA-B27. CTL specific for influenza virus lysed infected target cells matched for HLA-B27 only when they shared the same subtype. This indicates that the two subtypes of HLA-B27 detected by CTL function also as distinct elements in a self-restricted CTL response. Both subtypes were found among patients with ankylosing spondylitis.

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