Plasma phenylalanine levels in phenylketonuric heterozygous and normal adults administered aspartame at 34 mg/kg body weight
Toxicology, ISSN: 0300-483X, Vol: 20, Issue: 1, Page: 81-90
1981
- 28Citations
- 5Captures
Metric Options: Counts1 Year3 YearSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations28
- Citation Indexes23
- CrossRef23
- 18
- Policy Citations5
- 5
- Captures5
- Readers5
Article Description
Following administration of aspartame (34 mg/kg body wt) in orange juice, plasma concentrations of free amino acids were measured in 12 female subjects known to be heterozygous for phenylketonuria and 22 normal subjects (12 male, 10 female). No change in fasting plasma aspartate concentrations were noted after aspartame loading in either group. In normal male subjects, the mean (±S.D.) plasma phenylalanine concentration increased from a fasting value of 5.86 ± 1.25 μ mol/dl to a mean peak value of 12.0 ± 3.79 μ mol/dl. Plasma phenylalanine levels in normal female subjects increased from a mean fasting concentration of 4.83 ± 0.84 μ mol/dl to a mean peak value of 8.95 ± 1.49 μ mol/dl suggesting a more rapid absorption, metabolism, and/or clearance of phenylalanine by females. In female heterozygous subjects, the mean peak plasma phenylalanine concentration was significantly higher than in normal females. Plasma phenylalanine values increased from a mean fasting value of 5.92 ± 1.51 μ mol/dl to a mean peak value of 15.1 ± 4.67 μ mol/dl. Similarly, the area under the plasma phenylalanine concentration-time curve was significantly greater in heterozygous female subjects (21.36 ± 5.10 IU) than in normal female subjects (10.84 ± 2.32 IU). However, peak plasma phenylalanine levels were well below those associated with toxic effects in all cases.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/0300483X81901086; http://dx.doi.org/10.1016/0300-483x(81)90108-6; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0019419239&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/7268794; https://linkinghub.elsevier.com/retrieve/pii/0300483X81901086; http://linkinghub.elsevier.com/retrieve/pii/0300483X81901086; http://api.elsevier.com/content/article/PII:0300483X81901086?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:0300483X81901086?httpAccept=text/plain; http://dx.doi.org/10.1016/0300-483x%2881%2990108-6; https://dx.doi.org/10.1016/0300-483x%2881%2990108-6
Elsevier BV
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know