Differential regulation of C3 gene expression in human astroglioma cells by interferon-γ and interleukin-1β
Neuroscience Letters, ISSN: 0304-3940, Vol: 197, Issue: 2, Page: 121-124
1995
- 27Citations
- 7Captures
Metric Options: Counts1 Year3 YearSelecting the 1-year or 3-year option will change the metrics count to percentiles, illustrating how an article or review compares to other articles or reviews within the selected time period in the same journal. Selecting the 1-year option compares the metrics against other articles/reviews that were also published in the same calendar year. Selecting the 3-year option compares the metrics against other articles/reviews that were also published in the same calendar year plus the two years prior.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
Citation Benchmarking is provided by Scopus and SciVal and is different from the metrics context provided by PlumX Metrics.
Metrics Details
- Citations27
- Citation Indexes27
- 27
- CrossRef22
- Captures7
- Readers7
Article Description
In this report, we examined interferon-γ (IFN-γ) and interleukin-1β (IL-1β)-mediated regulation of the expression of C3, the third component of complement, in a human astroglioma cell line. Interleukin-1β induced C3 protein expression ten-fold more rapidly than IFN-γ. De novo protein synthesis was required for IFN-γ to stimulate C3 expression, while cycloheximide and IL-1β treatment of cells markedly increased C3 expression. Actinomycin D, inhibited C3 gene induction by IFN-γ and IL-1β suggesting that these cytokines act, in part, at the transcriptional level to enhance C3 expression. Understanding cytokine-mediated regulation of complement gene expression in the astrocyte is important in defining the role of these molecules in CNS inflammation and autoimmune diseases.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/030439409511923K; http://dx.doi.org/10.1016/0304-3940(95)11923-k; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0029096920&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/8552275; https://linkinghub.elsevier.com/retrieve/pii/030439409511923K; http://linkinghub.elsevier.com/retrieve/pii/030439409511923K; http://api.elsevier.com/content/article/PII:030439409511923K?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:030439409511923K?httpAccept=text/plain; http://dx.doi.org/10.1016/0304-3940%2895%2911923-k; https://dx.doi.org/10.1016/0304-3940%2895%2911923-k
Elsevier BV
Provide Feedback
Have ideas for a new metric? Would you like to see something else here?Let us know