Theophylline reduces poly(ADP-ribose) synthetase from chick embryo liver nuclei
Biochimica et Biophysica Acta (BBA) - General Subjects, ISSN: 0304-4165, Vol: 677, Issue: 1, Page: 63-68
1981
- 7Citations
- 2Captures
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Metrics Details
- Citations7
- Citation Indexes7
- CrossRef7
- Captures2
- Readers2
Article Description
The effect of theophylline on poly(ADP-ribosyl)ation was investigated. The poly(ADP-ribose) synthetase activity in vitro was markedly reduced in the liver nuclei prepared from theophylline-treated chick embryo. This reduction was not due to the enzyme inhibition by theophylline contamination in the nuclear fraction. The hydroxyapatite column chromatographic analysis of [ 3 H]adenosine-labelled poly(ADP-ribose) molecules formed in vivo revealed that the in vivo formation of poly(ADP-ribose) molecules was also decreased by theophylline administration. The theophylline-induced reduction of poly(ADP-ribose) synthesis was not due to either low NAD levels or to a decrease in the chain length of the poly(ADP-ribose) molecule, rather this reduction was derived from a decrease in the number of poly(ADP-ribose) molecules. Possible mechanisms related to reduction of poly(ADP-ribose) synthesis in vivo are discussed.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/030441658190146X; http://dx.doi.org/10.1016/0304-4165(81)90146-x; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0019779782&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/6271249; https://linkinghub.elsevier.com/retrieve/pii/030441658190146X; http://linkinghub.elsevier.com/retrieve/pii/030441658190146X; http://api.elsevier.com/content/article/PII:030441658190146X?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:030441658190146X?httpAccept=text/plain; http://dx.doi.org/10.1016/0304-4165%2881%2990146-x; https://dx.doi.org/10.1016/0304-4165%2881%2990146-x
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