PlumX Metrics
Embed PlumX Metrics

Effect of proteoglycans on hydroxyapatite growth in vitro: the role of hyaluronan

Biochimica et Biophysica Acta (BBA) - General Subjects, ISSN: 0304-4165, Vol: 1158, Issue: 2, Page: 129-136
1993
  • 27
    Citations
  • 0
    Usage
  • 18
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

Article Description

The effect of cartilage proteoglycans on HA seed crystal growth was studied using a system providing constant supersaturation with respect to HA. The monomers were much less effective than the aggregates in reducing the rate of HA growth, which correlates with their affinity for the HA crystals. Hyaluronan, which is a normal constituent of the proteoglycan aggregates, behaved as a strong inhibitor of HA seed crystal growth and had an affinity constant similar to that of proteoglycan aggregates. The results indicate that inhibition of HA seed crystal growth is mediated throught the interaction of hyaluronan with HA crystal surface and that the proteoglycans add to the volume of the adsorbate causing steric hindrance.

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know