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Biochemical analysis of degeneration and regeneration in rat soleus muscle induced by venom from three subspecies of Daboia russelli

Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, ISSN: 0305-0491, Vol: 107, Issue: 2, Page: 231-240
1994
  • 12
    Citations
  • 0
    Usage
  • 6
    Captures
  • 0
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

  • Citations
    12
    • Citation Indexes
      12
  • Captures
    6

Article Description

To develop a clearer understanding of the biochemical mechanism of muscle degeneration and regeneration induced by a single dose of D. r. pulchella, D. r. russelli or D. r. siamensis venoms, we have correlated changes in the levels of a series of muscle structural proteins and proteolytic enzymes; the sequence of changes were broadly similar, although some differences were noted in relative myotoxicity and regeneration efficiency. The data suggest that activation of cathepsins B, L and D, and leucyl aminopeptidase may be of particular importance in the early stages of structural protein degradation, and are thus potential therapeutic targets to prevent myonecrosis following envenomation.

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