Biochemical analysis of degeneration and regeneration in rat soleus muscle induced by venom from three subspecies of Daboia russelli
Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, ISSN: 0305-0491, Vol: 107, Issue: 2, Page: 231-240
1994
- 12Citations
- 6Captures
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Article Description
To develop a clearer understanding of the biochemical mechanism of muscle degeneration and regeneration induced by a single dose of D. r. pulchella, D. r. russelli or D. r. siamensis venoms, we have correlated changes in the levels of a series of muscle structural proteins and proteolytic enzymes; the sequence of changes were broadly similar, although some differences were noted in relative myotoxicity and regeneration efficiency. The data suggest that activation of cathepsins B, L and D, and leucyl aminopeptidase may be of particular importance in the early stages of structural protein degradation, and are thus potential therapeutic targets to prevent myonecrosis following envenomation.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/0305049194900442; http://dx.doi.org/10.1016/0305-0491(94)90044-2; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0028047415&origin=inward; https://linkinghub.elsevier.com/retrieve/pii/0305049194900442; https://api.elsevier.com/content/article/PII:0305049194900442?httpAccept=text/xml; https://api.elsevier.com/content/article/PII:0305049194900442?httpAccept=text/plain; http://dx.doi.org/10.1016/0305-0491%2894%2990044-2; https://dx.doi.org/10.1016/0305-0491%2894%2990044-2
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