The protein kinase C inhibitor H-7 inhibits concanavalin A induced T-lymphocyte activation
General Pharmacology: The Vascular System, ISSN: 0306-3623, Vol: 20, Issue: 5, Page: 585-588
1989
- 2Citations
- 1Captures
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Article Description
1.1. 1-(5-isoquinoline sulfonyl)-2-methylpiperazine (H-7), a protein kinase C inhibitor, was found to inhibit con A stimulated [3H]thymidine incorporation and cytosolic protein kinase C (PKC) activation in T-lymphocytes of mouse spleen.2.2. The inhibitory effect of H-7 was both concentration and time-dependent.3.3. H-7 exerted no inhibition when T-lymphocytes have been preincubated with con A for 10 hours or longer.4.4. These results support the notion that PKC is an important element of the con A mitogenic signal transduction mechanism and the PKC signal is completed within the first 10 hr of con A incubation.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/0306362389900906; http://dx.doi.org/10.1016/0306-3623(89)90090-6; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0024432501&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/2606326; https://linkinghub.elsevier.com/retrieve/pii/0306362389900906; http://dx.doi.org/10.1016/0306-3623%2889%2990090-6; https://dx.doi.org/10.1016/0306-3623%2889%2990090-6
Elsevier BV
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