Dopamine D 1 binding sites in the striatum of the mutant mouse weaver
Neuroscience, ISSN: 0306-4522, Vol: 28, Issue: 1, Page: 69-82
1989
- 19Citations
- 13Captures
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Metrics Details
- Citations19
- Citation Indexes19
- 19
- CrossRef14
- Captures13
- Readers13
- 13
Article Description
In the weaver mouse there is a major abnormality in the dopamine-containing innervation of the striatum. Dopamine islands form during development, along with some innervation of the non-islandic matrix; but during the first postnatal month much of the islandic innervation degenerates and there is a failure of the normal postnatal development of the diffuse nigrostriatal innervation. In the experiments reported here we analysed the distribution of D 1 dopamine receptor-related binding sites in the weaver striatum in an effort to test the relationship between the dopamine-containing innervation of the striatum and the synthesis and distribution of dopamine receptors there. Dopamine D 1 receptor binding sites labeled by the D 1 specific antagonist [ 3 H]SCH 23390 were studied in the striatum of 7-day and adult homozygous weaver (wv/wv) and homozygous control (+/+) mice. Saturation analysis of [ 3 H]SCH 23390 binding in adult animals suggested that the dissociation constants of the binding sites are similar in mutants and controls. The B max values in the striatum of weavers were 16% higher than in the controls when the data were expressed as fmoles/mg protein. The protein content of the adult weaver's striatum was decreased by 15 to 30%, however, so that when values were expressed as fmoles/section, no significant difference between values in weavers and homozygous controls were found. Quantitative autoradiography supported the results of saturation analysis. We conclude that the apparent increase of [ 3 H]SCH23390 binding sites in the mutants occurred as the result of shrinkage of the weaver's caudoputamen and that dopamine D 1 receptor binding sites in the caudoputamen, as assessed with [ 3 H]SCH 23390, are normal.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/0306452289902339; http://dx.doi.org/10.1016/0306-4522(89)90233-9; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0024473164&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/2527338; https://linkinghub.elsevier.com/retrieve/pii/0306452289902339; http://dx.doi.org/10.1016/0306-4522%2889%2990233-9; https://dx.doi.org/10.1016/0306-4522%2889%2990233-9
Elsevier BV
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