PlumX Metrics
Embed PlumX Metrics

EVIDENCE FOR AN EARLY INFLAMMATORY RESPONSE IN THE CENTRAL NERVOUS SYSTEM OF MICE WITH SCRAPIE

Neuroscience, ISSN: 0306-4522, Vol: 74, Issue: 1, Page: 1-5
1996
  • 183
    Citations
  • 0
    Usage
  • 62
    Captures
  • 1
    Mentions
  • 0
    Social Media
Metric Options:   Counts1 Year3 Year

Metrics Details

Article Description

In Alzheimer's disease, the most prevalent of the neurodegenerative diseases, inflammation of the CNS contributes to the pathology and is a target for therapy. [13, 18, 19] In contrast, the group of neurodegenerative conditions known as the Prion Diseases have been widely reported as lacking any inflammatory elements [5, 23] despite the many similarities between the pathologies of Alzheimer's Disease and Prion Diseases. [10] We have found evidence for an inflammatory component in mouse scrapie, characterized by microglial activation and T-lymphocyte recruitment, which appears long before any clinical signs of the disease and spreads along well-defined anatomical pathways. These observations emphasize the potential value of murine scrapie as a model for studying the inflammatory pathology of other neurodegenerative diseases. Copyright © 1996 IBRO. Published by Elsevier Science Ltd.

Provide Feedback

Have ideas for a new metric? Would you like to see something else here?Let us know