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Effects of calcium channel blockers on coronary vasoconstriction induced by endothelin-1 in closed chest pigs

Journal of the American College of Cardiology, ISSN: 0735-1097, Vol: 16, Issue: 5, Page: 1296-1303
1990
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Article Description

The purpose of this study was to determine the effects of endothelin-1 on the coronary vascular bed of closed chest pigs. Endothelin-1 (3 to 30 pmol/kg body weight) was selectively administered into the left anterior descending coronary artery. Coronary blood flow and epicardial vessel diameter were measured by quantitative arteriography. Arterial pressure increased after a 30 pmol/kg dose and heart rate was not changed.

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