Extrachromosomal circular DNAs and genomic sequence plasticity in eukaryotic cells
Mutation Research/DNAging, ISSN: 0921-8734, Vol: 237, Issue: 5, Page: 271-292
1990
- 157Citations
- 89Captures
- 2Mentions
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Example: if you select the 1-year option for an article published in 2019 and a metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019. If you select the 3-year option for the same article published in 2019 and the metric category shows 90%, that means that the article or review is performing better than 90% of the other articles/reviews published in that journal in 2019, 2018 and 2017.
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Metrics Details
- Citations157
- Citation Indexes156
- 156
- CrossRef83
- Patent Family Citations1
- 1
- Captures89
- Readers89
- 89
- Mentions2
- References2
- 2
Article Description
The ability of eukaryotic organisms of the same genotype to vary in developmental pattern or in phenotype according to varying environmental conditions is frequently associated with changes in extrachromosomal circular DNA (eccDNA) sequences. Although variable in size, sequence complexity, and copy number, the best characterized of these eccDNAs contain sequences homologous to chromosomal DNA which indicates that they might arise from genetic rearrangements, such as homologous recombination. The abundance of repetitive sequence families in eccDNAs is consistent with the notion that tandem repeats and dispersed repetitive elements participate in intrachromosomal recombination events. There is also evidence that a fraction of this DNA has characteristics similar to retrotransposons. It has been suggested that eccDNAs could reflect altered patterns of gene expression or an instability of chromosomal sequences during development and aging. This article reviews some of the findings and concepts regarding eccDNAs and sequence plasticity in eukaryotic genomes.
Bibliographic Details
http://www.sciencedirect.com/science/article/pii/092187349090009G; http://dx.doi.org/10.1016/0921-8734(90)90009-g; http://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&scp=0025672711&origin=inward; http://www.ncbi.nlm.nih.gov/pubmed/2079966; http://linkinghub.elsevier.com/retrieve/pii/092187349090009G; http://api.elsevier.com/content/article/PII:092187349090009G?httpAccept=text/xml; http://api.elsevier.com/content/article/PII:092187349090009G?httpAccept=text/plain; https://linkinghub.elsevier.com/retrieve/pii/092187349090009G; http://dx.doi.org/10.1016/0921-8734%2890%2990009-g; https://dx.doi.org/10.1016/0921-8734%2890%2990009-g
Elsevier BV
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