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6 New immunosuppressive treatment in transplantation medicine

Baillière's Clinical Gastroenterology, ISSN: 0950-3528, Vol: 8, Issue: 3, Page: 455-464
1994
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Article Description

Currently, the standard immunosuppressive regimen in organ transplantation is centred around cyclosporin. However, despite the use of this drug, rejection is not uncommon and it is associated with significant side-effects. Novel drugs and regimens have been developed to combat allograft rejection. Although FK506 has a similar mode of action and toxicity profile to cyclosporin, results, particularly in the rescue situation, have been encouraging. Sodium brequinar and rapamycin inhibit lymphocyte proliferation and may be most effective when used in combination with cyclosporin.

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